Hospital da Luz Lisboa has successfully performed the first robotic transperineal prostate biopsies in the Iberian Peninsula, using the Biobot system (ISR´OBOT – Mona Lisa 2.0). This groundbreaking procedure further strengthens Hospital da Luz’s position as one of Europe’s leading centres in robotic surgery and diagnostic innovation. Internationally recognized as a leader in Robotic Surgery, Hospital da Luz Lisboa has been a national pioneer in transperineal biopsies with elastic fusion for more than five years. This project is the result of close collaboration between the Urology Department, led by Dr. Kris Maes , and the Department of Imaging, headed by Dr. Augusto Gaspar . The imaging preparation of the procedure, including segmentation and identification of suspicious lesions, is carried out by Prof. Dr. Adalgisa Guerra . This information is then integrated through elastic fusion with the 3D ultrasound image produced by the urologist, ensuring precise localization of the lesions. The new Biobot system introduces next-generation elastic fusion technology, in which the robotic arm accurately tracks the position of the lesion and guides the surgeon to the optimal direction and depth for each biopsy. This significantly enhances procedural accuracy, allowing the target to be reached consistently and surpassing even the most experienced human performance. The biopsies are performed through a small transperineal access, significantly reducing discomfort and minimizing the risk of bleeding and infection to virtually zero. Carried out under sedation and in an ambulatory setting, the procedure requires only one puncture on each side of the prostate. The Urology team at Hospital da Luz Lisboa, composed of Dr. João Pina and Dr. Kris Maes, has already successfully performed eight procedures using this technology. The Biobot is the first robot specifically designed to enhance the accuracy of early prostate cancer detection while significantly improving patient comfort.